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( A ) Uniform manifold approximation and projection (UMAP) plot showing clustering of intestinal epithelial cell types isolated from the crypts of WT mice and analyzed by single-cell RNA sequencing

Strong outcomes there would strengthen the case for approval and help define who benefits most

In particular, mast cells signal to microglia, the resident immune cells of the brain, priming them toward a pro-inflammatory phenotype

One last category, called multivesicular liposomes (MVL), consists in a giant vesicles entrapping multiple liposomes (Figure 3)