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The titration protocol (starting at 2 mg and increasing every four weeks) is essential for tolerability

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These include for example arterial plasma concentration as an input signal for compartmental or graphical modeling of radioligand/target receptor interactions such as Binding Potential (BP), a well understood and validated vascular contribution to the PET signal in tissue as well as the possibility of using brain regions without receptor expression as reference tissue

Some experts believe that low levels of carnitine contribute to muscle weakness frequently seen in people with this eating disorder