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According to the World Health Organization (WHO), mercury and hazardous substances in cosmetics can cause kidney damage, skin rashes, discoloration, scarring, increased susceptibility to infections, anxiety, depression, psychosis, and peripheral neuropathy
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In contrast, LCA primarily inhibits apoptosis in damaged cells by disrupting mitochondrial function and mimics growth factors to activate the Wnt/-catenin pathway, thereby maintaining stem cell characteristics and driving aberrant proliferation (Farhana et al., 2016) (Figure 2A)
High out-of-pocket costs can limit access and slow adoption
Most treatment protocols run between 4 and 12 weeks, and patients often find that benefits like reduced pain, faster healing, and improved mobility persist for several months after the final injection
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