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Rapid weight loss can alter hormone levels and bone turnover, so providers may slow titration if weight loss occurs faster than expected

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In SUSTAIN 6, a placebo-corrected heart rate increase of 2.75 beats per minute (bpm) was observed for semaglutide 0.5 mg, and 3.2 bpm for the 1.0 mg dosage ( In addition, no increase in cardiovascular outcomes were observed in SUSTAIN 6 and PIONEER 6, which is reassuring given the initial fear of adverse cardiac events with increased resting heart rates

Kahn, so be sure to speak with your doctor about your nutrient levels before starting a GLP-1

Bile helps break down fats in food