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The development of drug resistance is a challenge for the use of adjuvant therapies in breast cancer patients [69], and studies suggest that ROS may play an important role in the production of drug-resistant cells [70]
a , Dose-response curves showing relative cell number after 72 h of treatment of HCC-1806 cells with vincristine (0-5 nM) in the presence of the MRP1 inhibitor MK-571 (0-15 M) (n = 8 technical replicates from one experiment)
PubMed Pickart L, Vasquez-Soltero JM, Margolina A (2014)
STAT3, in particular, is activated by cytokines such as IL-6 and plays a critical role in both systemic fibrotic diseases and ovarian cancer 61,62
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