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2 Several factors contribute to this: AEDs such as sodium valproate, carbamazepine, gabapentin, and pregabalin are associated with weight gain Seizure-related fatigue and activity restrictions can reduce physical activity levels Some people with epilepsy experience changes in appetite regulation Obesity itself has been associated with a 2.3-fold increased risk of drug-resistant epilepsy 3 This creates a cycle where AEDs contribute to weight gain, and excess weight may worsen seizure control
The result is that LR3 in serum behaves largely as if IGFBPs are absent, with the bulk of administered compound remaining free and receptor-available
13 , e1002179 (2016)
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