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Pancreas GLP-1 and GIP stimulate insulin secretion GLP-1 suppresses glucagon secretion during hyperglycemia GIP suppresses glucagon secretion during hyperglycemia and stimulates secretion during euglycemia and hypoglycemia Brain GLP-1 and GIP suppress hunger Stomach GLP-1 slows gastric emptying Fat tissue GIP increases fatty acid and glucose uptake by fat tissue [1,2,3] Tirzepatide Tirzepatide is a dual GLP-1 / GIP receptor agonist that mimics the actions of GLP-1 and GIP
Who should avoid Tirzepatide: Tirzepatide (Mounjaro, Zepbound) carries similar restrictions and is contraindicated in: Individuals with a personal or family history of MTC Those with MEN 2, due to the same cancer-related concerns People who have experienced severe gastrointestinal issues, such as chronic pancreatitis or gastroparesis Patients with a known hypersensitivity to tirzepatide or any of its components As always, anyone considering these medications should talk with their healthcare provider about their personal health history and risk factors
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Others need the full 200mcg range
This holistic approach to treatment underscores the importance of addressing both the physical and mental aspects of obesity, paving the way for a more sustainable and fulfilling lifestyle change
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