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As a peptide, Epitalon faces major pharmacokinetic challenges, particularly poor oral bioavailability due to enzymatic degradation in the gut

doi: 10.1016/j.atherosclerosis.2017.04.001 131 PoulterNRPrabhakaranDCaulfieldM

3 In a pre-specified analysis of time to first MACE-5, a composite of all-cause death, heart attack, stroke, heart failure event or coronary revascularization, there were 44 events in the Retatrutide group versus 52 in the placebo group, yielding a hazard ratio of 0.82 (95% CI: 0.55 to 1.22)

Interestingly, the metabolic improvements from significant weight loss (24.2% on average) are typically associated with improvements in fatty liver disease indicators rather than liver stress

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