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Tirzepatide at higher doses produced larger average weight loss numbers in trials, sometimes in the mid-teens as a percent of body weight

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Most studies focus on oral supplements, though, not injections, and results are usually seen alongside diet and exercise changes

Neurologic and cognitive concerns (e.g., migraines) and neurodevelopmental symptoms: Findings are mixed across studies and effect sizes are generally small, so we interpret results cautiously and prioritize whole-person assessment over single-gene conclusions