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Both isoforms of GAD have been identified in pancreatic beta cells, GAD65 being the predominant isoform in rat and human beta cells, while mice beta cells only express GAD67 [48]

The step-wise dose increases exist to manage GI adaptation

If gastrointestinal side effects are contributing to thirst, anti-nausea medications prescribed by your healthcare provider may help reduce fluid losses and improve overall comfort

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GLP-1 is released in the gut in the presence of glucose and stimulates the release of insulin from pancreatic B cells, enabling fine control of blood sugar levels