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Novo Nordisk developed it as a long-acting version of the naturally occurring hormone, engineered with specific amino acid substitutions that extend its duration of action from minutes to days
In scientific literature, AOD9604 is recognized as a modified analog of the natural hGH fragment, featuring a disulfide bridge between cysteine residues (Cys182 and Cys189) that stabilizes its tertiary structure and enhances metabolic stability
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