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2 Natural bioactive as multitarget therapeutics in metabolic and liver disorders Naturally occurring flavonoids help manage type 2 diabetes by modulating key glucose-metabolizing enzymes

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Patients should be advised to: Eat smaller, more frequent meals rather than large portions, which can exacerbate delayed gastric emptying Reduce intake of gas-producing foods such as beans, cruciferous vegetables, carbonated beverages, and high-fat meals Consider limiting foods high in fermentable oligosaccharides, disaccharides, monosaccharides, and polyols (FODMAPs) as a trial if symptoms persist (ideally with dietitian guidance) Chew food thoroughly and eat slowly to reduce air swallowing Stay well-hydrated with non-carbonated fluids throughout the day to help prevent constipation Avoid lying down immediately after meals to facilitate gastric emptying Medication timing and dosing strategies can also help minimize bloating

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