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Animal studies have demonstrated that GLP-1 receptors are present in the mesolimbic reward pathway, including the ventral tegmental area and nucleus accumbensbrain regions implicated in food reward and addictive behaviors

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63 Thus, removal of the GB should theoretically result in a marked suppression of Gpbar1/TGR5-dependent metabolic signaling emanating from the GB, and a subsequent systemic influence on metabolic homeostasis

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