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Relationships of clinical, physiologic, and inflammatory factors to extracellular BAL fluid and intracellular GSH and GSSG IL-13 upregulates 15LO1 pathway and lowers intracellular GSH IL-13 increases the expression and activity of 15LO1, while inducing binding to PEBP1 (6, 7, 10, 13)

Expression levels of tight junction proteins ZO-1 , O ccludin , and Claudin-1 were restored, which may explain the amelioration of inflammation

An age-dependent increase the glycoprotein CD38, may contribute to cellular NAD + depletion and impaired mitochondrial function

Five studies involving 825 exposed pregnancies and 592,714 comparator pregnancies evaluated first-trimester exposure and major congenital malformations