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A study involving the TAM-resistant cell lines named MCF-7/LCC2 and MCF-7/LCC9 reported that the combined use of curcumin and TAM resulted in synergistic growth inhibition, an increase in the sensitivity of MCF-7/LCC2 and MCF-7/LCC9 cells to TAM, and a reduction in IC 50 of TAM (Jiang et al., 2013)

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Conversely, in conditions of ER stress, Ca 2+ is released in excess and accumulates in the mitochondria, causing the mPTP opening and the depolarization of the inner membrane 50