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Senescent cells overexpress FOXO4, which sequesters p53 to prevent apoptosis in so-called zombie cells
That said, this remains a conceptual observation drawn from each compounds individual trial data rather than a finding from any study that administered them together, and no combined-use protocol or dosing framework has been established or validated in peer-reviewed research
[14] [15] To minimise this risk, the UK SmPC recommends gradual dose titration, starting at 2.5 mg once weekly and increasing every four weeks as tolerated, up to a maximum of 15 mg weekly
Effect of vitamin C and its derivatives on collagen synthesis and cross-linking by normal human fibroblasts
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