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this activates the tubulo-glomerular feedback responsible for afferent arteriole dilation and efferent arteriole constriction and, ultimately, leads to glomerular hyperfiltration and hypertension

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46 However, a switch study examining triple therapy with exenatide, sitagliptin, and metformin found a clinically insignificant additional lowering of A1C (0.3%) after 20 weeks of follow-up