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The core difference is this: phentermine pushes the nervous system to switch off hunger with an amphetamine-like stimulus, while semaglutide works on a hormonal pathway your body already uses to signal that youve had enough

This can increase side effects like nausea and affect your alcohol tolerance

Several of the women said the GLP-1 medications had a similar effect: It quieted the chaos in their brain and enabled them to think through their actions rather than respond impulsively to their cravings

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This third mechanism glucagon-driven energy expenditure is the critical differentiator