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Time spend in elevated plus maze closed and open arms were significantly increased and decreased respectively in stroke, CKD and CKD+Stroke group animals as compared to Sham group

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N Engl J Med 385(16):14511461 Nassif ME, Windsor SL, Borlaug BA, Kitzman DW, Shah SJ, Tang F, Khariton Y, Malik AO, Khumri T, Umpierrez G et al (2021) The SGLT2 inhibitor dapagliflozin in heart failure with preserved ejection fraction: a multicenter randomized trial

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doi:10.1158/1078-0432.CCR-10-0041