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When paired with a healthy diet and regular exercise, these supplements can complement the medication and contribute to better outcomes

Research indicates that lean body mass can account for as much as 40% of total weight loss during treatment, and weight-loss medications can reduce calorie consumption by 16-39%

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Profile 3: Poorly Controlled or Unstable Psychiatric Illness Semaglutide and tirzepatide carry no specific psychiatric black box warning, but the FDA's Adverse Event Reporting System (FAERS) contains post-marketing reports of suicidal ideation associated with GLP-1 agents, prompting the FDA to open a signal evaluation in 2023 [7]

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