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Our current findings in aging or HFD-fed mice with abrogation of improved lipid tolerance, despite reduced DPP-4 activity and increased GLP-1 levels, suggest that the concept of GLP-1 resistance should be further explored in studies examining the GLP-1dependent control of TG excursion

As these compounds progress through clinical development, they may eventually provide validated, prescription-grade alternatives to research-grade PTide treatments

However, higher-risk patientsincluding those with active gastrointestinal symptoms, recent dose increases, gastroparesis, or obesity with GERDmay be advised to stop once-weekly injectable semaglutide approximately one week before the procedure based on individualized evaluation by their surgical team

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