HI can develop acutely or chronically during the prenatal (maternal factors such as hypotension, infection, hypoxia), perinatal (umbilical cord accidents, uterine rupture, placental factors), or postnatal period (shock, anemia, respiratory, or cardiac arrest) 134
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For systemic or injectable use, the safest guidance this article can offer is that it falls outside the validated evidence base and should not be undertaken casually
For brand-name pens: Manufacturer expiration dates allow longer storage, typically 18 to 24 months from manufacturing
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