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GLP-1 meds stimulate insulin production when blood sugar is high, stop the liver from releasing excess sugar and slow stomach emptying to prevent blood sugar spikes after meals

For some people, these side effects can disrupt their sleep, but the majority of users adapt quickly

The hypothalamus contains a dense population of GLP-1 receptors

NICE guidelines recommend GLP-1 receptor agonists as add-on therapy for type 2 diabetes when glycaemic targets are not met with other treatments

Similarly, M1-type microglia exhibit reduced susceptibility to ferroptosis compared to M2-type microglia, likely due to high expression of inducible nitric oxide synthase (iNOS) in M1 cells (381383)