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Stimulated cells were collected for RNA and protein extraction

Considering these changes in T2DM and the critical role of GLP-1 in glucose homeostasis, strategies for managing T2DM based on this hormone include addressing the differentiation of L-cells, increasing the endogenous production and secretion of GLP-1 through stimulants, extending the half-life of GLP-1 by inhibiting its degrading enzyme and targeting GLP-1R using its agonists

[17] Hasbi H, Sonjaya H, Gustina S

Other pharmacotherapies not based on entero-pancreatic hormones Several therapies that are not based on entero-pancreatic hormones are currently under evaluation for obesity and they represent further therapeutic options, considering their distinct mechanism of WL to the entero-pancreatic hormone therapies