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For muscle conditions , the recommended dose is 250 mg/d approximately

IGF-1 suppresses pro-inflammatory cytokine production (notably TNF-alpha and IL-6) through PI3K/Akt signaling

This can lower blood glucose levels and reduce insulin resistance, making it particularly useful for people with type 2 diabetes or prediabetes

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If three or more cortisol indicators persist (wired at night and tired in the morning, 2 to 3 pm crash, evening cravings without hunger, disrupted sleep, stalled loss despite adherence), consider diurnal salivary cortisol testing (section 9)