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Occurred in 8.8% of participants on 9 mg and 20.9% on 12 mg, compared to 0.7% on placebo Dose-dependent (higher dose, higher risk) Generally described as mild Rarely led to discontinuation Why this matters: Dysesthesia was not reported in the Phase 2 trial

Anticipated Utilization Increases Expanded Eligibility: Coverage for obesity treatment could lead to a 40%60% increase in GLP-1 utilization over the first two years, with an estimated 1.52.5 million additional beneficiaries initiating therapy annually across Medicare and Medicaid

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