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Future work should focus on head-to-head comparison between ketamine and esketamine, longer follow-up time, optimized dosage regimens for ketamine, its mechanism of action with respect to MDD and suicidal ideation, and disparities in efficacy between various demographic subgroups

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Cycle Guidelines (Both Routes) Approach Short reference Duration 4 weeks Review Point Week 4 Best For Initial research planning window aligned with the shortest published mouse studies

These windows are aggregated from clinic and research-community summaries, not from a single controlled trial of the blend

This effect is most pronounced during initial treatment and tends to lessen with continued use