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consider ECG if clinically indicated Nutritional status : Assess current dietary intake, eating patterns, and screen for disordered eating behaviours Mental health evaluation : Screen for depression, anxiety, or other psychiatric comorbidities that may affect treatment adherence or outcomes Weight and metabolic parameters : Record baseline weight, BMI, waist circumference, and relevant blood tests (HbA1c, lipid profile, renal function) Pregnancy status : Exclude pregnancy and discuss contraception requirements (Wegovy is contraindicated in pregnancy) Treatment should begin with a dose of 0.25 mg once weekly, increasing every 4 weeks (0.5 mg, 1.0 mg, 1.7 mg) to reach the maintenance dose of 2.4 mg if tolerated

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Glucagon-like peptide-1 analogs mitigate neuroinflammation in Alzheimers disease by suppressing NLRP2 activation in astrocytes