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Haematological symptoms are among the earliest manifestations and include: Fatigue and generalised weakness Pallor due to anaemia (which may be macrocytic, though this is not universal) Shortness of breath on exertion Palpitations or tachycardia Neurological symptoms can be particularly concerning and may include: Peripheral neuropathy with tingling, numbness, or burning sensations in the hands and feet (paraesthesia) Loss of vibration sense and proprioception Ataxia and difficulty with balance or coordination Cognitive impairment, including memory problems and difficulty concentrating Mood disturbances, including depression and irritability In patients with diabetes, distinguishing between diabetic neuropathy and B12 deficiency-related neuropathy can be challenging, as both conditions may coexist
The absence of B12 in Zepbound's formulation means that patients requiring both medications will need two separate products
The gel base give an immediate improvement and then breaks down over a period of weeks
3: Matek D, Matek I, Japjec M, Matek M, Prenc J, Staresinic B, Staresinic E, Prtoric A, Sikiric S, Beketic Oreskovic L, Oreskovic I, Strbe S, Kordic M, Tvrdeic A, Seiwerth S, Sikiric P, Boban Blagaic A, Skrtic A, Bojanic I, Dobric I, Staresinic M
Several peer-reviewed studies have produced encouraging preliminary findings
