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Systemic inflammation is problematic

GLP-1R reduces oxidative damage accumulation by modulating autophagy-related proteins and scavenging damaged mitochondria while increasing superoxide dismutase (SOD) and glutathione peroxidase activities, reducing the generation of lipid peroxidation products, inhibiting the NF-B signaling pathway, and decreasing proinflammatory factor expression to reduce neuroinflammation (Ma et al., 2018

The rapid rise in type 1 and type 2 diabetes among the aging population will present significant issues for the German Diabetes Medications system in the years to come

2012 Dec 15;162(1):20-6

Thats not how its ever worked