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Finally, since the mechanism of action of the GSH-pocket binders and the VP1 lipid-pocket binders is quite separate, they should act additively as either inhibitors or stabilisers, with reduced risk of resistance mutations

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I discussed the roles of the three dietary components of Metabolic Engineering (i.e., Zone diet, omega-3 fatty acids, and polyphenols) in increasing AMPK activity in two of my most recent books, The Mediterranean Zone and The Resolution Zone (4,5)