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PF-06882961 was a partial agonist in recruiting Arr2 (EC 50 = 490 nM, E max = 36%), while exenatide (Arr2 EC 50 = 9.0 nM, E max = 75%) and liraglutide (Arr2 EC 50 = 20 nM, E max = 99%) were respectively 54- and 23-fold more potent with greater E max values

9111.4 g/mol 83-amino acid modified IGF-1: 13-AA N-terminal extension + Arg3 substitution Class Research Status Preclinical Half-Life 20-30 hours (vs 12-15 minutes for native IGF-1) Routes Category Growth Hormone Peptides

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