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Human gain-of-function MC4R variants show signaling bias and protect against obesity

The evidence base includes early pharmacology, animal research, a small healthy-volunteer PK/PD study, and a controlled phase 2 postoperative-ileus trial

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It binds to a series of receptors known as melanocortin receptors (MCRs)

When we compared Microdose GLP-1 Rx Program members who had the new features to those who didnt (pre-post analysis), we saw the new features drove over 20% higher D30 engagement in our key app behaviors (completing a lesson, logging meals, etc.)