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The potential benefits of combining GLP-1RAs with basal insulin are contemplated in the current position statement of both the American Diabetes Association (ADA) [1] and the American Association of Clinical Endocrinologists (AACE) [2]

These findings support future clinical trials to assess the efficacy of semaglutide in reducing the risk of kidney failure and cardiovascular complications in these patients. Journal reference: Apperloo, E.M., Gorriz, J.L., Soler, M.J

The clinical trial titration protocols used weekly dosing, and the body needs time to adapt to each new dose level

The implication was obvious and psychologically powerful

doi:10.1016/j.peptides.2004.12.038