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This fundamental difference in pharmacology means that there is no evidence that combining them provides additional benefits, and there is potential for additive adverse effects, particularly cardiovascular strain and gastrointestinal side effects
Patients may also have a harder time losing weight if they are on certain medications at the same time as a GLP-1 that can promote weight gain, such as certain antidepressants and beta blockers, Glickman says
That shift is not subtle
Jalil, P
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