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Nuclear factor erythroid 2-related factor 2 (Nrf2) functions as a transcription factor and a central regulator of the bodys oxidative stress response 11,12 , so that activating Nrf2 holds promise as an effective therapeutic strategy in OA

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This enzyme converts cysteine to cystathionine and its absence in egtA 26933 may be to ensure cysteine flux is available to facilitate increased GSH biosynthesis (Supplementary Table S1)

This is due to the stimulation of collagen production, which begins to replenish the skin's firmness and elasticity

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