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However, the simultaneous GLP-1 and GIP agonism appears to counterbalance this effect while still allowing glucagon to drive its metabolic benefits
There is no formal definition, but in the athlete community, microdosing typically means staying at or below 0.5mg weekly semaglutide rather than titrating up to the standard 1.7mg or 2.4mg therapeutic doses
Beyond these direct costs, long-term use is another factor
The authors emphasized that these agents are most likely to improve outcomes by addressing the cardiometabolic drivers of excess morbidity and mortality rather than replacing established psychiatric treatments
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