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An anti-diabetes agent protects the mouse brain from defective insulin signaling caused by Alzheimers disease-associated A oligomers
Why Tirzepatide outperforms other options
Subsequently, Moore proposed the hypothesis that intestinal secretions might have a glycemic-lowering effect in diabetics, which was the first study to suggest an effect of intestinal secretions on blood glucose (Moore, 1906), and in the 1960s a team of researchers in the UK and the US independently discovered the incretin effect, in which oral glucose markedly stimulates insulin secretion, setting the stage for the subsequent development of incretin (Elrick et al., 1964
Underlying causes unaddressed
It also fits patients with migraine (topiramate is approved for migraine prevention) who could get dual benefit
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