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Phase 3 trials and post-approval studies will eventually characterize the cardiovascular profile in detail

These subjective reports are impossible to verify without controlled trials

Time- and dose-related improvements in insulin sensitivity were similar to the temporal patterns of body weight loss with retatrutide in both the MASLD cohort reported here and in the full cohort of people with obesity 13

Selective inhibition in astrocytes alone was sufficient to prevent non-cell-autonomous neuronal loss and prolong survival, as a mechanism of neurodegeneration driven by reactive astrocytes (Smith et al., 2020)

However, we can speculate that this may be caused by the onset of telogen effluvium