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2023;388:e22

After GLP-1 binding to GLP-1R, this complex could upregulate cAMP thereby activating the PKA/CREB pathway [24]

[10] reported that metformin acutely and selectively increased plasma levels of GLP-1 in mice, even in the absence of concomitant oral glucose administration, while it did not increase plasma levels of the other incretin hormone, glucose-dependent insulinotropic polypeptide (GIP), or, curiously, peptide YY, a gastrointestinal hormone co-localised with GLP-1 in L cells

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When used properly and under medical supervision, side effects are rare