Administration Injectable GLP-1 medications: Self-administered subcutaneous injection Small needle, minimal discomfort for most Common injection sites: abdomen, thigh, upper arm Rotate sites to prevent tissue irritation Most are once-weekly (semaglutide, tirzepatide, dulaglutide) Oral semaglutide (Rybelsus): Must be taken on empty stomach No more than 4 oz water Wait 30 minutes before eating or taking other medications Daily dosing Long-Term Considerations Understanding the long-term picture helps with treatment planning
The Best Keto Chocolate Cake A rich, fudgy diabetes-friendly chocolate cake with under 1g sugar per slice Two-Ingredient Skinny Dark Chocolate Raspberry Bark Just chocolate and raspberrieseasy, low-carb, and satisfying Get the recipe
Key points Obesity is a risk factor for developing osteoarthritis (OA), gout, rheumatoid arthritis (RA), psoriatic arthritis (PsA) and axial spondyloarthritis (axSpA), and is associated with higher disease activity and/or severity, and worse response to common treatments
Several peptides in this category, including MOTS-c, have shown benefits for glucose metabolism and insulin sensitivity
European Journal of Clinical Pharmacology, 28 (5), 567-571