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Rihm et al., 2019

Bibcode:2005FEBSL.579..803M

GEP44 was developed based on extensive structureactivity relationship studies and earlier preliminary in vivo studies that demonstrated its greater efficacy at reducing both food intake and body weight compared to the agonist peptide, Ex-4, without triggering gastrointestinal distress (as assessed by kaolin intake and behavioral scoring as a proxy for nausea in rats and direct evidence of emesis in shrews) 16

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Side effects are the number one reason people discontinue semaglutide prematurely, and most of those side effects are manageable with the right strategies