Under inflammation, glia cells become activated, leukocytes are recruited across the BBB, and the BBB itself breaks down, with alterations in paracellular and transcellular transport and tight junction protein expression [63,64,65,66,67]
The metabolism and survival of chondrogenic progenitors and chondrocytes are greatly compromised by ROS including free radicals, peroxides, and superoxide anions 118,119,120
That's all they're doing with the bone mineral density is they're turning on a gene that tells you to increase your bone mineral density
Rare allergic reactions (particularly in individuals sensitive to sulfa, due to methionine)
As with any supplement, it's best to consult a doctor to ensure the ingredient is safe for you to take