Lower body mass, different hepatic clearance, and higher GI sensitivity mean women typically respond at lower per-week totals and tolerate slower titration better
Across human studies and reviews, adverse effects are uncommon at typical supplemental intakes, and when side effects do occur, they are usually mild and gastrointestinal in nature.12 13 44 A safety-focused review published in European Review for Medical and Pharmacological Sciences summarized available clinical and non-clinical data on myo-inositol and reported that only very high intake (around 12g per day) was consistently associated with side effects specifically mild gastrointestinal symptoms such as nausea, gas/flatulence, and diarrhea.44 The authors also noted that the severity of these effects did not increase with higher doses
10.1126/science.1226767 Science 4 Barry-LaneP
Therefore, the optimized B12 profile of Sample K not only contributes to nutritional adequacy but also supports athletic performance, recovery, and long-term health outcomes within plant-based dietary frameworks
Wettergren A, Wojdemann M, and Holst JJ
