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Absolute contraindications to GLP-1 receptor agonists include: Personal or family history of medullary thyroid carcinoma Multiple Endocrine Neoplasia syndrome type 2 Previous serious hypersensitivity reaction to the specific GLP-1 drug Pregnancy and breastfeeding (for medications approved for weight management: Wegovy, Saxenda, and Zepbound) Patients should maintain age-appropriate cancer screening regardless of GLP-1 use

J Trans Med (2022) 20:120

If your physician seems dismissive or uncomfortable discussing weight management, seeking a second opinion or consulting an obesity medicine specialist is entirely appropriate

Psychiatry 13 , 382 (2023)

Exercise Regularly: Engage in moderate-intensity physical activities like walking, cycling, or yoga to increase glutathione levels over time and reduce oxidative stress