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Compared with native GLP-1 which has a half-life of only a couple of minutes because the enzyme DPP-4 rapidly inactivates it semaglutide carries an Aib substitution at position 8 that resists DPP-4 cleavage, plus a C18 fatty-diacid side chain that binds albumin and extends its half-life to about a week

The molecule has to penetrate the stratum corneum (the skin's outer barrier) to reach the dermis where collagen is actually produced

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[19] Thanks Don't exercise at least 2 days after treatment, as the capillaries damaged during your injection need rest in order to heal properly