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Then, either NADPH-dependent glutamate dehydrogenases (GDH) or other transaminases, including glutamate oxaloacetate transaminase 2 (GOT2) and glutamate pyruvate transaminase 2 (GPT2), convert glutamate into a-KG to meet the need for corresponding amino acids

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In clinical trials like the landmark FLOW study, semaglutide demonstrated strong renoprotective (kidney-protecting) benefits, significantly slowing down the progression of chronic kidney disease (CKD) and reducing kidney function decline in patients with type 2 diabetes

doi: 10.3389/fimmu.2022.1089987 137 ZouJReddivariLShiZLiSWangYBretinAet al

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