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Warming the oil helps it become more fluid and more accessible to spread

GLP-1 receptors located in hypothalamic and brainstem centers are known to influence hunger signaling and satiety pathways, while GIP and glucagon receptor signaling contribute to nutrient sensing and metabolic feedback mechanisms

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Overall, the study supports the real-world effectiveness of oral semaglutide for glycemic control, body weight reduction, lipid markers, and ALT improvement in adults with T2D who met Finnish reimbursement criteria, while highlighting the need for further controlled research on longer-term persistence and liver-related outcomes