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Although the pathogenetic role of oxidative stress in these diseases is well established, there is still limited evidence on the therapeutic role of GSH in such conditions

Some approved drugs such as Rufinamide, Oxcarbazepine, and Phenytoin targeting Na + channels to control the seizures and the treatment of epilepsy (Perucca, 2021)

Figure 4F) methanone] is a natural phenolic compound that belongs to the benzophenone family and is found in Morus alba L ., Garcinia mangostana L

Future studies on the role of oxidative stress in the comorbidity of both diseases should further clarify the nature of these processes, identify common mechanisms involved in the course of diseases, and consider the role of antioxidants in the development of therapeutic strategies

The threshold plasma selenium level showing the optimal GPx activity has been worked out in the range of ~ 90120 g/L for human [30,31,32,33]