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"But we were quite surprised that it was the number was as high as it was." Silverstein and his colleagues calculated the inappropriately prescribed shots needlessly cost the province's health-care system $45.6 million annually

Finally, although the correlations between the metabolome and microbiome were established using robust statistical analyses, there was limited statistical power and there are also limitations to the statistical approaches used herein (e.g., log transformation to resolve non-normal distribution and/or heteroscedasticity 103 )

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